报告题目:MINFLUX Nanoscopy: Superresolution post Nobel
报告时间:2018年10月31日(周一)14:30-16:00
报告地点: 闵行校区李政道图书馆B1报告厅
报告人:Stefan Walter Hell
德国马普生物物理化学研究所所长
2014年诺贝尔化学奖获得者
语言:英文
报告人简介:
Stefan Walter Hell,德国物理学家,马克思普朗克生物物理化学研究所所长。1981年进入德国海德堡大学学习,1990年获得海德堡大学物理学博士学位,1991年至1993年在德国海德堡欧洲分子生物学实验室从事研究工作,1993年至1996年在芬兰图尔库大学物理系从事研究工作,期间1993年至1994年担任英国牛津大学访问科学家,1997年到德国马普生物物理化学研究所从事研究工作。
Stefan Walter Hell教授主要成就为超分辨显微成像,他首次提出突破光学衍射极限的受激辐射损耗的超分辨成像原理,并且成功地在仪器上得到验证。他已在Nature, Science, Nature Method, PNAS等著名学术期刊发表论文400多篇,获得国际知名奖项30多项,包括Leibniz Prize (2008), the Lower Saxony State Award (2008), the Otto-Hahn-Prize in Physics (2009), the Kavli Prize(2014)等。由于在“超分辨荧光显微镜”领域的杰出贡献,他与埃里克•贝齐格,威廉•莫纳共同获得2014年诺贝尔化学奖。
报告内容简介:
The 2014 Nobel Prize in Chemistry was awarded jointly to W.E. Moerner, Eric Betzig and myself“for the development of super-resolved fluorescence microscopy”.More than 125 years after Ernst Abbe’s definition of the supposedly insurmountable diffraction resolution limit, “[our] microscopes crossed the threshold”, as the Nobel poster put it. The result has been the breathtaking development of far-field optical super-resolution microscopy or, in short, ‘nanoscopy‘ as an entire field over the past years.
A fresh look at the foundationsshows that an in-depth description of the basic principles of nanoscopy spawns new powerful concepts such as MINFIELD, MINFLUX and DyMIN. Although they differ in some aspects, these concepts harness a local intensity minimum (of a doughnut or a standing wave) for determining the coordinate of the fluorophore(s) to be registered. Most strikingly, by using an intensity minimum of the excitation light to establish the fluorophore position, MINFLUX nanoscopy has obtained the ultimate (super)resolution: the size of a molecule.