贺新义

姓名: 贺新义

职称: 研究员

E-Mail: xyhe@sjtu.edu.cn

个人主页:http://mml.sjtu.edu.cn/

联系电话:62932943-2131

  • 个人简历:

    个人简介

    研究兴趣一直聚焦于核苷酸代谢,包括基础代谢中 DNA 磷硫酰化,羟甲基化,糖羟甲基化等异常修饰形成和识别的分子机理;以及次级代谢中具有良好生物活性的核苷类抗生素的生物合成,如杀稻瘟菌素,米多霉素和精霉素的生合成的酶学研究。近五年来已发表第一或通讯作者 SCI 论文 14 篇,合作论文发表在《自然》杂志上并被评为 2011 年度中国科学十大进展;获得授权发明专利 3 项;先后主持 4 项国家自然科学基金项目。 2005 年获中国高等学校十大科技进展; 2010 年度获得欧宝app官方网站下载晨星青年学者奖励计划 A 类。

    教育经历

    2004.03-2008.06欧宝app官方网站下载博士

    1998.09-2001.06华中农业大学硕士

    1994.09-1998.06华中农业大学学士

    工作经历

    2015.01-欧宝app官方网站下载微生物代谢国家重点实验室,研究员

    2014.01- 2014.12欧宝app官方网站下载微生物代谢国家重点实验室,副研究员

    2012.08-2013.08美国新英格兰生物实验室, 访问学者

    2010.01- 2013.12欧宝app官方网站下载微生物代谢国家重点实验室,副教授

    2001.09- 2009.12欧宝app官方网站下载生命学院,讲师、助教

    荣誉奖励

    2010欧宝app官方网站下载晨星青年学者奖励计划A

    2005中国高等学校十大科技进展

    学会兼职:
    Journal of Biochemistry and Molecular Biology Research编委

    1. 细菌核苷酸修饰及识别的酶学研究
    2. 核苷类抗生素的生物合成

  • 1.Han T, Yamada-Mabuchi M, Zhao G, Li L, Liu G, Ou HY, Deng Z, Zheng Y*,He X*. Recognition and cleavage of 5-methylcytosine DNA by bacterial SRA-HNH proteins.Nucleic Acids Res.2015 Jan; 43(2):1147-59.

    2. Zhao G, Wu G, Zhang Y, Liu G, Han T, Deng Z,He X*. Structure of theN-glycosidase MilB in complex with hydroxymethyl CMP reveals its Arg23specifically recognizes the substrate and controls its entry.Nucleic Acids Res.2014 Jul; 42(12):8115-24.

    3. Liu G, Ou HY, Wang T, Li L, Tan H, Zhou X, Rajakumar K, Deng Z*,He X*. Cleavage of phosphorothioated DNA and methylated DNA by the type IV restriction endonuclease ScoMcrA.PLoS Genet.2010 Dec 23; 6(12):e1001253.

    4. Liu G, Zhang Z, Zhao G, Deng Z, Wu G*,He X*. Crystallization and preliminary X-ray analysis of the type IV restriction endonuclease ScoMcrA fromStreptomyces coelicolor, which cleaves both Dcm-methylated DNA and phosphorothioated DNA.Acta Crystallogr F Struct Biol Commun.2015 Jan 1; 71(Pt 1):57-60.

    5. Feng J, Wu J, Gao J, Xia Z, Deng Z,He X*. Biosynthesis of the β-methylarginine residue of peptidyl nucleoside arginomycin inStreptomyces arginensisNRRL 15941.Appl Environ Microbiol.2014 Aug; 80(16):5021-7. doi: 10.1128/AEM.01172-14.

    6. Feng J, Wu J, Dai N, Lin S, Xu HH, Deng Z,He X*. Discovery and characterization of BlsE, a radical S-adenosyl-L-methionine decarboxylase involved in the blasticidin S biosynthetic pathway.PLoS One.2013 Jul18; 8(7):e68545.

    7. Li L, Wu J, Deng Z, Zabriskie TM,He X*.Streptomyces lividansblasticidin S deaminase and its application in engineering a blasticidin S-producing strain for ease of genetic manipulation.Appl Environ Microbiol.2013 Apr; 79(7):2349-57.

    8. Wu J, Li L, Deng Z, Zabriskie TM,He X*. Analysis of the mildiomycin biosynthesis gene cluster inStreptoverticillum remofaciensZJU5119 and characterization of MilC, a hydroxymethyl cytosyl-glucuronic acid synthase.Chembiochem. 2012 Jul 23; 13(11):1613-21.

    9. Yu Q, Du A, Liu T, Deng Z*,He X*. The biosynthesis of the polyether antibiotic nanchangmycin is controlled by two pathway-specific transcriptional activators.Arch Microbiol.2012 Jun; 194(6):415-26.

    10. Ou HY, Kuang SN,He X, Molgora BM, Ewing PJ, Deng Z, Osby M, Chen W, Xu HH*. Complete genome sequence of hypervirulent and outbreak-associatedAcinetobacter baumanniistrain LAC-4: epidemiology, resistance genetic determinants and potential virulence factors.Sci Rep.2015 Mar 2; 5:8643.

    11. Bi D, Xu Z, Harrison EM, Tai C, Wei Y,He X, Jia S, Deng Z, Rajakumar K, Ou HY*. ICEberg: a web-based resource for integrative and conjugative elements found in Bacteria.Nucleic Acids Res.2012 Jan; 40(Database issue):D621-6.

    12. Li J, Qu X,He X, Duan L, Wu G, Bi D, Deng Z, Liu W, Ou HY*. ThioFinder: a web-based tool for the identification of thiopeptide gene clusters in DNAsequences.PLoS One. 2012; 7(9):e45878.

    13. Xu F, Kong D,He X, Zhang Z, Han M, Xie X, Wang P, Cheng H, Tao M, Zhang L, Deng Z, Lin S*. Characterization of streptonigrin biosynthesis reveals a crypticcarboxyl methylation and an unusual oxidative cleavage of a N-C bond.J Am Chem Soc.2013 Feb 6; 135(5):1739-48.

    14. Gu TP, Guo F, Yang H, Wu HP, Xu GF, Liu W, Xie ZG, Shi L,He X, Jin SG, IqbalK, Shi YG, Deng Z, Szabó PE, Pfeifer GP, Li J*, Xu GL*. The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes.Nature.2011 Sep4; 477(7366):606-10.

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