冯雁

姓名: 冯雁

职称: 教授

E-Mail: yfeng2009@sjtu.edu.cn

个人主页:

联系电话:34207189

  • 个人简历:

    个人简介

    主要从事分子酶学研究,主攻酶结构-功能关系、酶分子进化及合成生物学。承担和参加科技部973计划项目、863计划项目、国家自然科学基金等省部级科研项目多项,已在J Biol Chem, J Mol Biol等国内外学术刊物上发表论文80余篇,作为副主编编写《酶工程》专著一部,研究成果获吉林省科技进步一等奖和二等奖各一项。先后获得教育部优秀青年教师、国务院政府特殊津贴、教育部新世纪人才和吉林省高级专家等奖励及称号。

    教育经历

    1991.09-1994.06 白求恩医科大学博士

    1986.09-1989.06吉林大学硕士

    1981.09-1986.06吉林大学学士

    工作经历

    2009.04-欧宝app官方网站下载生命科学技术学院,欧宝app官方网站下载特聘教授

    生命科学技术学院生物技术系,主任

    微生物代谢国家重点实验室,副主任²

    2003.09-2003.12美国National Cancer Institute,合作研究、访问学者

    2000.01-2009.03吉林大学分子酶学工程教育部重点实验室,教授、主任

    1998.03-2000.03日本National Institute of Bioscience and Human-Technology,访问学者

    1995.01-1999.12吉林大学酶工程国家重点实验室,副教授

    1994.09-1996.06日本National Institute of Bioscience and Human-Technology,博士后研究人员

    1991.10-1994.12吉林大学酶工程国家重点实验室,讲师

    1989.07-1991.09吉林大学酶工程国家重点实验室,助教

    荣誉奖励

    2008 中共吉林省委吉林省人民政府授予“吉林省高级专家”

    2007吉林省第九批有突出贡献的中青年专业人才

    2006 教育部新世纪优秀人才支持计划

    2005中共吉林省委吉林省人民政府授予“吉林省优秀留学回国人员”

    2005吉林省人民政府人才开发资金资助(一级)

    2004享受政府特殊津贴

    2003教育部优秀青年教师资助计划

    2003长春市人事局“优秀留学回国人员”

    2003吉林省科技厅“杰出青年”基金

    2001长春市高新技术产业开发区“优秀留学人员创业带头人”

    学会兼职

    中国生物化学与分子生物学学会理事

    中国生物物理学会 理事中国生物化学与分子生物学学会酶学专业委员会副主任

    中国生物化学与分子生物学学会蛋白质专业委员会委员

    中国微生物学会酶工程专业委员会委员

    中国生物化学与生物物理学报编委

    J Mol Catal B: Enzym编委


  • 1. 酶结构-功能关系
    2. 酶分子进化
    3. 合成生物学

  • 1. Bai A, Zhao X, Jin Y, Yang G,Feng Y*. A novel thermophilic β-glucosidase fromCaldicellulosiruptor bescii: Characterization and its synergistic catalysis with other cell ulases.J Mol Catal B-Enzym, 2013, 85(86):248–256.

    2. Wang Y, Tang R, Tao J, Wang X, Zheng B,Feng Y*. Chimeric cellulase matrix for investigating intramolecular synergism between non-hydrolytic disruptive functions of carbohydrate-binding modules and catalytic hydrolysis.J Biol Chem, 2012, 287(35):29568-29578.

    3. Zheng B, Yang W, Zhao X, Wang Y, Lou Z, Rao Z,Feng Y*.Crystal structure of hyperthermophilic endo-β-1, 4-glucanase: implications for catalytic mechanism and thermostability.J Biol Chem, 2012, 287(11): 8336-8346.

    4. Li B, Yang G, Wu L,Feng Y*. Role of the NC-loop in catalytic activity and stability in lipase fromFervidobacterium changbaicum.PLoS ONE, 2012, 7(10):e46881.

    5. Wang Y, Li B, Han W, Yang G, Zhang Z,Feng Y*. Redesigning the active site of a carboxyl esterase from the archaeonArchaeoglobus fulgidusto improve sensitivity to organophosphorus compounds.Process Biochem, 2012, 47(12):2219–2226.

    6. Zhang Y, An J, Ye W, Yang G, Qian ZG, Chen HF, Cui L,Feng Y*. Enhancing the promiscuous phosphotriesterase activity of a thermostable lactonase (GkaP) for the efficient degradation of organophosphate pesticides.Appl Environ Microbiol, 2012, 78(18):6647-6655.

    7. Wang Y, Tang R, Tao J, Gao G, Wang X, Mu Y,Feng Y*. Quantitative investigation of non-hydrolytic disruptive activity on crystalline cellulose and application to recombinant swollenin.Appl Microbiol Biotechnol, 2011, 91(5):1353-1363.

    8. Cai J, Xie Y, Song B, Wang Y, Zhang Z,Feng Y*.Fervidobacterium changbaicumLip1: identification, cloning, and characterization of the thermophilic lipase as a new member of bacterial lipase family V.Appl Microbiol Biotechnol, 2011, 89(5):1463-1473.

    9. Li Q, Li G, Ma F, Zhang Z, Zheng B,Feng Y*. Highly efficient ring-opening polymerization of ε-caprolactone catalyzed by a recombinant Escherichia coli whole-cell biocatalyst.Process Biochem, 2011, 46(2):477-481.

    10. Li Q, Yu S, Ma F,Feng Y*. Ring-opening polymerization of ε-caprolactone catalyzed by a novel thermophilic lipase fromFervidobacterium nodosum.Process Biochem, 2011, 46:253-257.

    11. Zhan D, Han W,Feng Y*. Experimental and computational studies indicate the mutation of Glu12 to increase the thermostability of oligomeric protease fromPyrococcus horikoshii.J Mol Model, 2011, 17(6):1241-1249.

    12. Liu C, Yang G, Wu L, Tian G, Zhang Z,Feng Y*. Switch of substrate specificity of hyperthermophilic acylaminoacyl peptidase by combination of protein and solvent engineering.Protein Cell, 2011, 2(6):497-506.

    13. Yang G, Rich JR, Gilbert M, Wakarchuk WW,Feng Y, Withers SG*. Fluorescence activated cell sorting as a general ultra-high-throughput screening method for directed evolution of glycosyltransferases.J Am Chem Soc, 2010, 132(30):10570-10577.

    14. Zheng B, Yang W, Wang Y, Lou Z,Feng Y*. Influence of the N-terminal peptide on the cocrystallization of a thermophilic endo-β-1, 4-glucanase with polysaccharide substrates.Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011, 67 (Pt 10):1218-1220.

    15. Wang Y, Wang X, Tang R, Yu S, Zheng B,Feng Y*. A novel thermostable cellulase fromFervidobacterium nodosum.J Mol Catal B Enzym, 2010, 66(3-4):294-301.

    16. Yu S, Yu S, Han W, Wang H,Feng Y*. A novel thermophilic lipase from Fervidobacterium nodosum Rt17-B1 representing a new subfamily of bacterial lipases.J Mol Catal B Enzym, 2010, 66(1-2):81-89.

    17. Yang G, Bai A,Feng Y*. Molecular redesign and construction of new biocatalysts.Curr Org Chem, 2010, 14(14):1407-1423.

    18. Yang G, Bai A, Gao L, Zhang Z, Zheng B,Feng Y*. Glu88 in the non-catalytic domain of acylpeptide hydrolase plays dual roles: Charge neutralization for enzymatic activity and formation of salt bridge for thermodynamic stability.Biochim Biophys Acta, 2009, 1794(1):94-102.

    19. Zhang Z, Zheng B, Wang Y, Chen Y, Manco G,Feng Y*. The conserved N-terminal helix of acylpeptide hydrolase from archaeonAeropyrum pernixK1 is important for its hyperthermophilic activity.Biochim Biophys Acta, 2008, 1784(9):1176-1183.

    20. Yu L, Pei X, Lei T, Wang Y,Feng Y*.Genome shuffling enhanced L-lactic acid production by improving glucose tolerance ofLactobacillus rhamnosus.J Biotechnol,2008, 134(1-2):154-159.

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