夏小霞

教授/长聘副教授

  • 电话:+86-021-34207254
  • 邮箱:xiaoxiaxia@sjtu.edu.cn
  • 地址:东川路800号生物药学楼3-303
  • 欧宝app官方网站下载教授,博士生导师,聚焦蛋白材料合成生物学研究。通过肽段模块的挖掘及重构,仿生及再设计人工蛋白质,在宿主微生物体内构建亚细胞器,对细胞生命活动进行代谢重塑;在体外制备智能仿生及生物医用材料。在Nat Chem Biol等高水平期刊发表论文60余篇。

学术经历

  • 2009年1月获韩国科学技术院(KAIST) 化学与生物分子工程博士学位,之后在韩国KAIST及美国Tufts大学从事博士后研究,于2012年9月加入欧宝app官方网站下载,入选上海市浦江人才计划(A类)。
  • 担任国际期刊Biotechnology Journal,ACS Biomaterials Science&Engineering及Metabolic engineering communications编委。

研究方向

人工无膜细胞器

解析蛋白相变组装机制,建立无膜细胞器的动态响应调控策略,发展微生物代谢时空调控的平台技术

人工蛋白材料创制

基于人工蛋白质的相变/组装构筑先进功能材料

代表论著

  • Chen MT†, Hu CF†, Huang HB, Qian ZG*,Xia XX*. Spatially directed biosynthesis of quantum dots via spidroin templating in Escherichia coli. Angew. Chem. Int. Ed., 2022, 61: e202214177.

    Qian ZG, Huang SC,Xia XX*. Synthetic protein condensates for cellular and metabolic engineering. Nat. Chem. Biol., 2022, 18: 1330-1340.

    Wei SP†, Qian ZG†, Hu CF†, Pan F, Chen MT, Lee SY,Xia XX*. Formation and functionalization of membraneless compartments in Escherichia coli. Nat Chem Biol, 2020, 16(10):1143-1148.

    Jin Q†, Pan F†, Hu CF, Lee SY,Xia XX*, Qian ZG*. Secretory production of spider silk proteins in metabolically engineered Corynebacterium glutamicum for spinning into tough fibers. Metab Eng, 2022, 70: 102-114.

    Qin N, Qian ZG, Zhou C,Xia XX*, Tao TH*. 3D electron-beam writing at sub-15 nm resolution using spider silk as a resist. Nat Commun 2021, 12: 5133.

  • Song WW†, Qian ZG†, Liu H, Chen HF, Kaplan DL,Xia XX*. On-demand regulation of dual thermosensitive protein hydrogels. ACS Macro Lett 2021, 10(4):395-400.

    Qian ZG, Pan F,Xia XX*. Synthetic biology for protein-based materials. Curr Opin Biotechnol, 2020, 65:197-204.

    Tian KK,Qian ZG,Xia XX*. Synthetic biology-guided design and biosynthesis of protein polymers for delivery. Adv. Drug Deliv. Rev., 2023, 194: 114728.

    Jiang J†, Zhang S†, Qian Z, Qin N, Song W, Sun L, Zhou Z, Shi Z, Chen L, Li X, Mao Y, Kaplan DL, Gilbert Corder SN, Chen X, Liu M, Omenetto FG,Xia XX*, Tao TH*. Protein bricks: 2D and 3D bio-nanostructures with shape and function on demand. Adv Mater, 2018, 1705919. (Selected as inside back cover).

    Huang SC†, Fan RX†, Tian KK,Xia XX*, Qian ZG*. Controllable fibrillization reinforces genetically engineered protein elastomer hydrogels. Biomacromolecules, 2021, 22: 961-970.

  • Xia XX†, Qian ZG†, Ki CS, Park YH, Kaplan DL, Lee SY*. Native-sized recombinant spider silk protein produced in metabolically engineered Escherichia coli results in a strong fiber. PNAS 2010, 107 (32): 14059-14063.

教学情况

  • 本科生专业课 代谢工程
  • 研究生核心课 合成生物学
Baidu
map