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  张诗宜

  张诗宜，男，1986年出生，博士，国家级青年人才项目获得者，欧宝app官方网站下载生物医学工程学院长聘副教授，博士生导师。2008年本科毕业于北京大学的化学与分子工程学院。2013年毕业于美国圣路易斯华盛顿大学，师从Karen Wooley院士，主要研究方向为可降解高分子材料的生物应用。2013-2016年，在美国麻省理工学院三院院士（科学院，工程院，医学院）Robert Langer教授课题组从事博士后研究，主要研究方向为胃肠道药物缓控释。在Nature Materials, Science Translational Medicine, Science Advances, Nature Communications, eLife, Journal of the American Chemical Society, ACS Nano, Advanced Materials, Advanced Functional Materials, Macromolecules and ACS Macro Letters等顶级学术期刊发表论文40余篇。申请了12项国际专利，其中8项成功转化。主导成立多家生物医药公司，3个项目推进到临床二期，5个项目获得临床批件。目前的研究方向主要围绕着抗癌药物的副作用，口服不吸收药物，减肥药展开。研究思路是做原创的，有趣的，有临床意义的研究。

北京大学，本科，2004-2008

华盛顿大学圣路易斯，博士，2008-2013

麻省理工学院，博士后，2013-2016

Wu, Y.; Xiang, L.; Zhao, X.; Liu, T.; Xiao, Y.; Cui, X.; Tang, F.; Liu, Z.; Zeng, J.; Zhang, S.*; Nat. Comm. (IF = 16.6) 2025 Accepted.

Liu, T.; Cui, X.; Chen, J.; Wang, J.; Wu, S.; Zhang, M.; Tang, F.; Xiao, Y.; Ren, J.; Zhang, Z.; Chen, Y.*; Zhang, S.*; " Oral Covalent Organic Frameworks as Dysbiosis-Mitigating Oxalate Sequestrants for Crystalline Nephropathy" Adv. Mater. (IF = 32.086) 2025, e08773.

Wu, M.; Zhang, S.*; Ren, J.* "AI-empowered digital design of zeolites: Progress, challenges, and perspectives" APL Mater. (IF = 5.3) 2025, 13, 020601.

Xia, L.; Wu, Y.; Zhao, L.; Chen. L.; Zhang, S.*; Wang, M.; Luo, J.* "Redefining the Game: MVAE-DFDPnet's Low-Dimensional Embeddings for Superior Drug-Protein Interaction Predictions" IEEE J. Biomed. Health Inform. (IF = 6.7) 2024, 28 (7), 4317-4324.

Xiang, L.; Chen, J.; Zhao, X.; Hu, J.; Yu, J.; Zeng, X.; Liu, T.; Ren, J. *; Zhang, S.*; "Synergistic Machine Learning Accelerated Discovery of Nanoporous Inorganic Crystals as Non-Absorbable Oral Drugs" Adv. Mater. (IF = 32.086) 2024, May 30:e2404688.

You, Q.; Chen, L.; Li, S.; Liu, M.; Tian, M.; Cheng, Y.; Xia, L.; Li, W.; Yao, Y.; Li, Y.; Zhou, Y.; Ma, Y.; Lv, D.; Zhao, L.; Wang, H.; Wu, Z.; Hu, J.; Ju, J.; Jia, C.; Xu, N.*; Luo, J.*; Zhang, S.* "Topical JAK Inhibition Ameliorates EGFR Inhibitor-induced Rash in Rodents and Humans" Sci. Transl. Med. (IF = 19.319) 2024, 16, eabq7074.

You, M.; Tian, M.; Fan, D.; Yang, B.; Liu, Z.; Zhang, S.* "Selection of GalNAc-conjugated siKeap1 as Disease-specific Delivery System for Chemotherapy-induced Liver Injury and Chronic Liver Disease" Nano Lett. (IF = 12.262) 2024, 24, 4, 1096–1105.

Liu, Z.; Xiang, L.; Tian, M.; Wang, H.; Zhao, X.; Liu, K.; Yu, J.; Liu, T.; Liu, S.; Mu, X.; Yang, B.; Zhang, S.*; Luo, J.* "A Counterion-free Strategy for Chronic Metabolic Acidosis Based on an Orally Administered Gut-restricted Inorganic Adsorbent" Adv. Mater. (IF = 32.086), 2023, 35(51), 2305992.

Tian, M.; Mu, X.; Fan, D.; Liu, Z.; Liu, Q.; Yue, K.; Song, Z.; Luo, J.; Zhang, S.* "A Transformable Mucoadhesive Microgel Network for Noninvasive Multimodal Imaging and Radioprotection of a Large Area of the Gastrointestinal Tract" Adv. Mater. , 2023, 35(40), 2303436

Xiang, J.; Wang, H.; Tao, Q.; Li, W.; Huang, Y.; Zhang, Y.; Yang, L.; Zhang, S.* " CDK4/6 inhibitor modulating active and quiescent intestinal stem cells for prevention of chemotherapy-induced diarrhea" J. Pathol. , 2023, 260(3), 235-247

Yang, B.; Xie, X.; Lv, D.; Hu, J.; Chen, Y.; Wu, Z.; Luo, S.; Zhang, S.* "Capecitabine induces hand-foot syndrome through elevated thymidine phosphorylase-mediated locoregional toxicity and GSDME-driven pyroptosis that can be relieved by tipiracil" Br. J. Cancer, 2022,128(2), 219-231.

Yang, J.; Wang, X.; Wang, B.*; Park, K.*; Wooley K. L.*; Zhang, S.* "Challenging the fundamental conjectures in nanoparticle drug delivery for chemotherapy treatment of solid cancers" Adv. Drug Deliv. Rev., 2022 109, 114525

Tian, M.; Fan, D.; Liu, Z.; Mu, X.; Tao, Q.; Yu, C.; Zhang, S.* "Oral Supramolecular Adsorbent for Preventing Chemo-Induced Gastrointestinal Mucositis & Microbial Dysbiosis and for Enhancing Chemoimmunotherapy" Adv. Mater., 2022,34(50), 2205299.

Chen, L.; You, Q.; Liu, M.; Li, S.; Wu, Z.; Hu, J.; Ma, Y.; Xia, L.; Zhou, Y.; Xu, N.*; Zhang, S.* "Remodeling of dermal adipose tissue alleviates cutaneous toxicity induced by anti-EGFR therapy" eLife, 2022 (11): e72443

Xie, X.; Chen, L.; Liu X.; Wu, Z.; Lv, D.; Ma, Y.; Luo, J.; Zhang, S.* "Prophylactic effect of nitric oxide donors on rat models of EGFR inhibitors induced-cutaneous toxicities" J. Invest. Dermatol., 2022, 142(1), 3052-3061.

Chen, L.; Wu, Z.; Yang, L.; Chen, Y.; Wang, W.; Cheng, L.; Li, C.; Lv, D.; Xia, L.; Chen, J.; Tang, L.*; Zhang, L.*; Zhang, S.*; Luo, J.* "Nitric Oxide in Multikinase Inhibitor-induced Hand-Foot Skin Reaction" Transl. Res., 2022, 245: 82-98

Chen, L.; You, Q.; Lv, D.; Li, S.; Zhang, S.* "GPCR-mediated EGFR transactivation ameliorates skin toxicities induced by afatinib" Acta. Pharmacol. Sin., 2021, 43: 1534–1543

Tian, M.; Xing, R.; Guan, J.; Yang, B.; Zhao, X.; Yang, J.; Zhan, C.*; Zhang, S.* "A Nanoantidote Alleviates Glioblastoma Chemotoxicity without Efficacy Compromise" Nano Lett. 2021, 21, 12, 5158-5166

Zhao, X.; Zhang, H.; Li, J.; Tian, M.; Yang, J.; Sun, S.; Hu, Q.; Yang, L.; Zhang, S.*;"Orally administered saccharide-sequestering nanocomplex to manage carbohydrate metabolism disorders" Sci. Adv., 2021, 7, 14, eabf7311

Bellinger, A. M.*; Jafari, M.*; Grant, T. M.*; Zhang, S. *; Slater, H.; Wenger, E.; Mo, S.; Lee, Y-A. L.; Mazdiyasni, H.; Kogan, L.; Barman, R.; Cleveland, C.; Booth, L.; Bensel, T.; Minahan, D.; Hurowitz, H. M.; Tai, T.; Daily, J.; Nikolic, B.; Wood, L.; Eckhoff, P.; Langer, R.; Traverso, G. "Oral, Ultra–long-lasting Drug Delivery: Application Toward Malaria Elimination Goals" Sci. Transl. Med. , 2016 16;8(365):365ra157 (* equal contribution)

Zhang, S.; Bellinger, A. M.; Glettig, D. L.; Barman, R.; Lee, Y.-A. L.; Zhu, J.; Cleveland, C.; Montgomery, V. A.; Gu, L.; Nash, L. D.; Maitland, D. J.; Langer, R.; Traverso G. "A pH-responsive Supramolecular Polymer Gel as an Enteric Elastomer for Use in Gastric Devices" Nat. Mater., 2015, 14, 1065-1071

转化医学与职业发展 (BME4203) 春季